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can be hydrolyzed by intracellular esterases to release the fluorescent fluorescein core
providing flexibility in protein labeling and tracking
This dual reactivity forces the tagged proteins into close proximity
527 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
planar structure around the boron-dipyrromethene core imparts exceptional photostability
Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan clip can be hydrolyzed by intracellularSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent
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